clinicalreports

EVALUATION OF THE
ANTIMUTAGENECITY OF THE
EXTRACT OF ASHSHIFA-1000

The alcoholic extracts of Ashshifa-1000 was tested for mutagenecity as indicated below:
1. To test the direct-acting mutagenic effect of the sample in TA98 (frame shift mutagens), TA
100 (base pair substituting mutagens) and TA 102 (oxidative mutagens).
2. To test the influence of the sample extract on direct-acting mutagens added to TA 98, TA
100 and TA 102.
The findings of the evaluation of the antimutagenicity of Ashshifa-1000 extract in Ames Salmonella microsome assay is given in TableVI.

Table-VI
EFFECT OF EXTRACT OF ASHSHIFA-1000 ON THE MUTAGENICITY
OF THE STANDARD MUTAGENS IN TA98, TA100 AND TA102

SR - Spontaneous Revertants :
SM - Standard Mutagen
Normal range of SR:
TA98 : 30-50
TA100 : 120-200
TA 102 : 240-320
It is quite clear from the table that the extract of Ashshifa-1000 did not niduce any mutation in the strains TA98, TA 100 and TA 102 showing its antimutagenic effect.